Table 3.
Changes in St George’s Respiratory Questionnaire (SGRQ) scores
| Immediate ART |
Deferred ART |
Difference in mean change from baseline* |
p value | 95% CI | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| n | Baseline* | Month 12* | Change from baseline† |
n | Baseline* | Month 12* | Change from baseline† |
||||
| Smokers | |||||||||||
| Total | 102 | 11·7 (94) | 10·6 (10·0) | −1·1 (11·1) | 119 | 12·8 (9·9) | 12·3 (10·4) | −0·5 (7·2) | −1·1 (1·1) | 0·34 | −3·3 to 1·1 |
| Symptoms | 111 | 20·8 (15·4) | 17·9 (14·8) | −2·9 (15·6) | 122 | 21·5 (16·5) | 23·1 (18·8) | 1·6 (15·8) | −4·8 (1·9) | 0·01 | −8·5 to −1·1 |
| Activity | 102 | 16·7 (14·5) | 14·6 (14·3) | −2·0 (14·5) | 119 | 17·5 (14·4) | 17·1 (16·0) | −0·3 (11·6) | −2·0 (1·6) | 0·23 | −5·2 to 1·2 |
| Impacts | 103 | 6·5 (8·5) | 6·4 (9·0) | −0·1 (11·4) | 119 | 8·0 (8·9) | 6·7 (8·5) | −1·2 (6·7) | 0·3 (1·1) | 0·76 | −1·8 to 2·4 |
| Non-smokers | |||||||||||
| Total | 241 | 9·8 (8·9) | 8·7 (8·6) | −1·1 (8·4) | 215 | 9·6 (8·9) | 10·0 (11·3) | 0·4 (10·5) | −1·4 (0·8) | 0·08 | −3·0 to 0·2 |
| Symptoms | 253 | 15·0 (14·0) | 13·2 (15·2) | −1·9 (14·7) | 226 | 14·1 (12·6) | 14·5 (15·6) | 0·4 (14·9) | −1·9 (1·2) | 0·13 | −4·3 to 0·5 |
| Activity | 246 | 14·8 (13·5) | 13·5 (13·4) | −1·3 (12·4) | 222 | 13·9 (13·7) | 14·6 (15·9) | 0·7 (15·2) | −1·6 (1·2) | 0·17 | −3·9 to 0·7 |
| Impacts | 248 | 6·4 (8·4) | 5·7 (8·2) | −0·7 (9·5) | 218 | 6·2 (8·2) | 6·4 (9·8) | 0·2 (10·4) | −0·8 (0·8) | 0·33 | −2·3 to 0·8 |
SGRQ scores were measured in participants randomly assigned to immediate versus deferred antiretroviral therapy (ART) initiation. Higher SGRQ scores indicate worse respiratory health status. The minimal clinically important difference in the total SGRQ score is 4 points; minimal clinically important differences for the symptoms, activity, and impact domains are not established.
*
Data are means (SD).
†
Data are means (SE) adjusted for baseline value.