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. 2016 Dec 19;6(2):206–218. doi: 10.1016/j.molmet.2016.12.005

Figure 4.

Figure 4

Expression and phosphorylation of proteins involved in the unfolded proteins response (UPR). (A) Protein kinase RNA-like ER kinase (PERK) phosphorylation in liver and epididymal adipose tissue; activating transcription factor 6 (ATF6α) expression in liver and epididymal adipose tissue; inositol requiring enzyme 1 (IRE1α) phosphorylation in liver and adipose tissue. (B and C) PERK phosphorylation densitometry in (B) liver and (C) adipose tissue. (D and E) ATF6α expression densitometry in (D) liver and (E) adipose tissue. (F and G) IRE1α phosphorylation densitometry in (F) liver and (G) adipose tissue. *p < 0.05 vs. C57BL/6J HFD, ˆp < 0.05 vs. iNOS KO HFD. Bars represent mean ± SEM from 4 to 8 mice. Similar results were observed when using delta percentage of baseline.