Table 1.
Patient demographics and clinical characteristics
| Liver Resection (n=480) |
Liver Transplant (n=128) |
p-value | |
|---|---|---|---|
| Age (years) | 66 (53-74) | 56 (50-62) | <0.001 |
| Male | 304 (63) | 99 (77) | 0.002 |
| White race | 392 (82) | 90 (70) | 0.013 |
| BMI (kg/m2) | 26 (23-30) | 27 (25-31) | 0.031 |
| Hepatitis B | 81 (17) | 9 (7) | 0.004 |
| Hepatitis C | 48 (10) | 87 (68) | <0.001 |
| History of alcohol abuse | 39 (8) | 36 (28) | <0.001 |
| Fibrosis | 108 (23) | n/a | |
| Cirrhosis | 94 (20) | 128 (100) | <0.001 |
| Alpha-fetoprotein | 13 (4-278) | 101 (18-167) | 0.208 |
| Albumin | 4.1 (3.7-4.3) | 3.3 (2.9-3.7) | <0.001 |
| Total bilirubin | 0.6 (0.5-0.9) | 1.4 (0.7-2.4) | <0.001 |
| Creatinine | 1.0 (0.9-1.2) | 0.9 (0.7-1.1) | 0.522 |
| INR | 1.0 (1.0-1.1) | 1.3 (1.1-1.5) | <0.001 |
| Platelets | 243 (183-333) | 77 (53-152) | <0.001 |
| Portal hypertension | 39 (8) | 128 (100) | <0.001 |
| CPT score | 5 (5-5) | 7 (6-9) | <0.001 |
| MELD score | 8 (6-9) | 13 (11-17) | <0.001 |
| Largest tumor diameter (cm) | 9.0 (6.5-12.9) | 4.1 (3.4-5.3) | <0.001 |
| Single tumor | 345 (72) | 28(22) | <0.001 |
| Size single tumor (cm) | 9.5 (7-13) | 5.9(5.3-6.0) | <0.001 |
| ≥ 2 tumors | 135 (28) | 100 (78) | <0.001 |
| Size largest tumor (cm) | 8.1 (5.5-12) | 3.9 (3-3-4.6) | <0.001 |
| Any pre-treatment | 26 (5.4) | 104 (81.3) | <0.001 |
| Preoperative TACE only | 25 (5.2) | 88 (68.8) | <0.001 |
| Preoperative therapy (other) | 1 (0.2) | 16 (12.5) | <0.001 |
Data reported as n (%) or as median (interquartile range)
Preoperative therapy other:
Resection: TACE and RFA (1 patient)
Transplant: RFA (5 patients); TACE and RFA (4 patients); radioembolization (3 patients); TACE and radioembolization (1 patient); bland embolization (1 patient); external beam radiation (1 patient).