Figure 4.

Effects of antibiotics on microbial communities in DFUs. (A) Boxplot showing the inter-visit Weighted UniFrac distances of subjects during exposure to antibiotics split by indication. Antibiotics given for the ulcer being studied produces greater community disruption than antibiotics given for other ulcers or other infections. Antibiotic class did not yield more information. (B) Boxplot showing the inter-visit distances of all samples binned by event type (complication, antibiotics, both, or none). Antibiotics and ulcer complications both disrupt the microbiota, and their combined effect is additive.