Table 4.
Changes in fibrosis–related peritoneal gene expression at day 49 in mice infected with S. epidermidis or S. epidermidis and sTLR2
| Gene Symbol | Description | S. epidermidisa | S. epidermidis+sTLR2 | sTLR2 Modulatory Effect, %c | ||
|---|---|---|---|---|---|---|
| Fold Changeb | P Valueb | Fold Changeb | P Valueb | |||
| Fasl | Fas ligand (TNF superfamily, member 6) | 2.6 | 0.24 | 0.9 | 0.91 | −105.2 |
| Mmp1a | MMP-1a (interstitial collagenase) | 0.5 | 0.001 | 0.7 | 0.21 | −48.1 |
| Mmp3 | MMP-3 | 0.4 | 0.01 | 0.9 | 0.51 | −87.7 |
| Mmp9 | MMP-9 | 0.4 | 0.02 | 0.5 | 0.02 | −16.6 |
| Timp1 | TIMP-1 | 0.6 | 0.22 | 0.3 | 0.04 | N/A |
N/A, not applicable.
a
Only statistically significant (P<0.05) S. epidermidis–induced ≤0.5- or ≥2-fold changes were considered.
b
Compared with the control group.
c
Compared with the effect of S. epidermidis treatment.