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. 2016 Jul 21;28(2):479–493. doi: 10.1681/ASN.2016010045

Figure 3.

Figure 3.

miR-146a is induced in vivo after renal IRI. (A) miR-146a levels in kidney transplant biopsies from patients with delayed graft function after kidney transplantation (n=19) compared with those from patients in stable condition at 3 months post-transplantation (n=14). (B) miR-146a levels at 10 days post-transplantation in urine samples from kidney transplant recipients who received a kidney from a deceased (n=35) or a living donor (n=16). (C) Ischemia-induced upregulation of miR-146a expression in C57BL/6 mouse kidneys (n=5–8) on days 2 and 7 after unilateral IRI (black bars) compared with in contralateral kidneys (white bars). (D) In situ hybridization for miR-146a in sections of the contralateral kidney (left panel) and the postischemic kidney (center panel) 7 days after IRI. Kidney sections from miR-146a−/− mice were used as controls (right panel). The results of quantitative PCR have been normalized to the RNU48 snRNA levels for human samples or the U6 snRNA levels for mouse samples. Data are presented as means±SEM. Original magnification, ×400. *P<0.05; **P<0.01.