Table 5.
Association of donor YKL-40 with 6-month eGFR, stratified by DGF status
| Tertile of YKL-40 (Range [ng/ml]) | N | Unadjusted | Adjusted for Donor Variablesa | Adjusted for Donor, Transport, and Recipient Variablesb | Adjusted for Donor, Transport, Recipient Variables, and Donor NGALc |
|---|---|---|---|---|---|
| Recipients without DGF | |||||
| T1 (<0.61) (referent) | n1=620 | 62.09 (59.97 to 64.21) | 54.81 (51.82 to 57.80) | 56.26 (52.87 to 59.65) | 55.69 (52.23 to 59.15) |
| T2 (0.61–3.31) | n2=588 | −2.29 (−5.19 to 0.61) | −0.15 (−2.66 to 2.36) | 0.50 (−2.01 to 3.01) | 1.17 (−1.43 to 3.76) |
| T3 (3.33–432.78) | n3=471 | −5.59 (−8.64 to −2.55) | −2.19 (−5.00 to 0.62) | −1.58 (−4.38 to 1.22) | 0.13 (−3.29 to 3.54) |
| Recipients with DGF | |||||
| T1 (<0.61) (referent) | n1=256 | 46.06 (42.97 to 49.15) | 41.15 (37.46 to 44.84) | 40.28 (35.84 to 44.72) | 39.95 (35.34 to 44.55) |
| T2 (0.61–3.31) | n2=240 | 0.04 (−4.52 to 4.59) | 3.17 (−0.93 to 7.27) | 3.48 (−0.63 to 7.59) | 3.74 (−0.48 to 7.97) |
| T3 (3.33–432.78) | n3=260 | 3.55 (−0.71 to 7.81) | 5.25 (1.19 to 9.32) | 5.93 (1.81 to 10.05) | 6.75 (1.49 to 12.02) |
Values are estimated mean eGFR (95% CI) for referent tertile (T1), and estimated mean difference (95% CI) for the other tertiles (T2 and T3). There was a significant interaction between the highest urinary YKL-40 tertile and DGF (P=0.001) in unadjusted analyses.
Donor variables used for adjustment: age (years), height (cm), weight (kg), black race, history of hypertension, history of diabetes, terminal serum creatinine, stroke as cause of death, and donation after circulatory determination of death status.
Includes all variables listed above plus the following transport and recipient variables: cold ischemia time (hours), age (years), black race, gender, previous kidney transplant, diabetes as the cause of ESRD, number of human leukocyte antigen mismatches, body mass index (kg/m2), duration of dialysis before transplant (months), and panel reactive antibody (%).
Includes all variables listed above plus log base 2–transformed donor urine NGAL.