Table 3.
Frequency of secondary outcomes (cause of death, cause of allograft failure, and early complications), by cause of ESRD, n=107,778
| Outcome | Primary GN subtypes | Secondary GN subtypes | Non-GN Comparator Groups | |||||
|---|---|---|---|---|---|---|---|---|
| FSGS n=13,272 | IgAN n=7379 | MN n=2249 | MPGN n=1980 | LN n=5884 | Vasculitis n=1367 | DN n=57,190 | ADPKD n=18,457 | |
| Causes of death, n (%) | ||||||||
| Cardiovascular | 641 (4.8) | 154 (2.1) | 146 (6.5) | 113 (5.7) | 308 (5.2) | 46 (3.4) | 6431 (11.2) | 742 (4.0) |
| Infection | 241 (1.8) | 63 (0.9) | 43 (1.9) | 42 (2.1) | 133 (2.3) | 34 (2.5) | 2157 (3.8) | 297 (1.6) |
| Malignancy | 165 (1.2) | 62 (0.8) | 47 (2.1) | 32 (1.6) | 49 (0.8) | 24 (1.8) | 847 (1.5) | 290 (1.6) |
| Other | 546 (4.1) | 154 (2.1) | 115 (5.1) | 104 (5.3) | 256 (4.4) | 78 (5.7) | 5085 (8.9) | 776 (4.2) |
| Missing cause | 539 (4.1) | 135 (1.8) | 112 (5.0) | 99 (5.0) | 207 (3.5) | 79 (5.8) | 6111 (10.7) | 818 (4.4) |
| Patient still alive at last follow-up | 11,141 (83.9) | 6811 (92.3) | 1786 (79.4) | 1590 (80.3) | 4932 (83.8) | 1106 (80.9) | 36,559 (63.9) | 15,534 (84.2) |
| Causes of allograft failure, n (%) | ||||||||
| Primary nonfunction | 178 (1.3) | 44 (0.6) | 20 (0.9) | 22 (1.1) | 59 (1.0) | <10 (<1%) | 643 (1.0) | 142 (0.8) |
| Graft thrombosis | 148 (1.1) | 66 (0.9) | 21 (0.9) | 18 (0.9) | 67 (1.1) | 17 (1.2) | 505 (0.9) | 196 (1.1) |
| Acute rejection | 430 (3.2) | 156 (2.1) | 54 (2.4) | 53 (2.7) | 244 (4.1) | 28 (2.1) | 1231 (2.2) | 284 (1.5) |
| Chronic rejection | 973 (7.3) | 363 (4.9) | 172 (7.6) | 170 (8.6) | 514 (8.7) | 75 (5.5) | 3226 (5.1) | 756 (4.1) |
| Infection | 94 (0.7) | 32 (0.4) | 25 (1.1) | 16 (0.8) | 38 (0.7) | <10 (<1%) | 528 (0.8) | 128 (0.7) |
| Recurrent GN | 355 (2.7) | 121 (1.6) | 75 (3.3) | 110 (5.6) | 67 (1.1) | <10 (<1%) | 253 (0.4) | 57 (0.3) |
| Other | 509 (3.8) | 176 (2.4) | 82 (3.6) | 111 (5.6) | 241 (4.1) | 39 (2.9) | 1854 (3.2) | 440 (2.4) |
| Death | 1204 (9.1) | 343 (4.7) | 267 (11.9) | 190 (9.6) | 472 (8.0) | 171 (12.5) | 14,124 (24.7) | 2036 (11.0) |
| Missing cause | 464 (3.5) | 180 (2.4) | 68 (3.0) | 83 (4.2) | 197 (3.4) | 20 (1.5) | 2732 (4.8) | 310 (1.7) |
| Graft functioning at last follow-up | 8921 (67.2) | 5902 (79.9) | 1466 (65.1) | 1207 (61.0) | 3988 (67.7) | 994 (72.7) | 32,094 (56.1) | 14,108 (76.4) |
| Early post-transplant complications, n (%) | ||||||||
| DGF | 2032 (15.3) | 662 (9.0) | 329 (14.6) | 267 (13.5) | 751 (12.8) | 163 (11.9) | 11,222 (19.6) | 2230 (12.1) |
| Missing | 52 (0.4) | 27 (0.4) | 12 (0.5) | 17 (0.9) | 36 (0.6) | <10 (<0.5) | 299 (0.5) | 66 (0.4) |
| Oliguria | 1056 (8.0) | 385 (5.2) | 164 (7.3) | 133 (6.7) | 400 (6.8) | 84 (6.1) | 5476 (9.6) | 1196 (6.5) |
| Missing | 2847 (21.5) | 1531 (20.8) | 543 (24.1) | 518 (26.2) | 1299 (22.1) | 285 (20.9) | 13,712 (24.0) | 4240 (23.0) |
| Acute rejection | 237 (1.8) | 122 (1.7) | 32 (1.4) | 31 (1.6) | 112 (1.9) | 21 (1.5) | 895 (1.6) | 219 (1.2) |
| Missing | 5930 (44.7) | 3057 (41.4) | 1138 (50.6) | 1040 (52.5) | 2689 (45.7) | 563 (41.2) | 28,150(49.2) | 8346 (45.2) |
DN, diabetic nephropathy.