Table 3.
Correlation of STAT activation levels and renal function in diabetic mice.
| Variables | Glomeruli | Tubulointerstitium | ||
|---|---|---|---|---|
| P-STAT1+ Cells | P-STAT3+ Cells | P-STAT1+ Cells | P-STAT3+ Cells | |
| Pearson r (P Value) | Pearson r (P Value) | Pearson r (P Value) | Pearson r (P Value) | |
| KBWR, g/kg | 0.6055 (<0.01) | 0.7109 (<0.001) | 0.4717 (<0.05) | 0.5995 (<0.01) |
| UAC, μg/μmol | 0.5991 (<0.01) | 0.7149 (<0.001) | 0.7423 (<0.001) | 0.6723 (<0.01) |
| SCr, mmol/L | 0.7719 (<0.01) | 0.6587 (<0.01) | 0.6646 (<0.01) | 0.5635 (<0.05) |
| Glomerular area, μm2 | 0.9058 (<0.001) | 0.8097 (<0.001) | N.D. | N.D. |
| Mesangial area, % PAS | 0.6822 (<0.01) | 0.4587 (NS) | N.D. | N.D. |
| Fibrosis, % sirius red | 0.6608 (<0.01) | 0.6963 (<0.01) | 0.6185 (<0.01) | 0.7312 (<0.001) |
| T cells, CD3+ | 0.7011 (<0.01) | 0.7621 (<0.001) | 0.6417 (<0.01) | 0.6082 (<0.01) |
| Macrophages, F4/80+ | 0.6793 (<0.01) | 0.7954 (<0.001) | 0.6847 (<0.01) | 0.5603 (<0.02) |
| Kim-1 mRNA, a.u. | 0.6886 (<0.01) | 0.4226 (NS) | 0.5866 (<0.01) | 0.5592 (<0.02) |
| Ccl2 mRNA, a.u. | 0.8077 (<0.001) | 0.7229 (<0.001) | 0.7942 (<0.001) | 0.8257 (<0.001) |
| Ccl5 mRNA, a.u. | 0.7662 (<0.001) | 0.6541 (<0.01) | 0.6608 (<0.01) | 0.5621 (<0.02) |
| Tnfα mRNA, a.u. | 0.6726 (<0.01) | 0.7607 (<0.001) | 0.6502 (<0.01) | 0.6262 (<0.01) |
| Col I mRNA, a.u. | 0.7594 (<0.001) | 0.6959 (<0.01) | 0.7824 (<0.001) | 0.8384 (<0.001) |
| Fn mRNA, a.u. | 0.8198 (<0.001) | 0.7768 (<0.001) | 0.8386 (<0.001) | 0.7230 (<0.001) |
| Tgfβ mRNA, a.u. | 0.7893 (<0.001) | 0.6412 (<0.01) | 0.6869 (<0.01) | 0.6777 (<0.01) |
Pearson correlation analysis between P-STAT1/3 immunostaining and renal variables in diabetic mice at 16 weeks of age. KBWR, kidney/body weight ratio; SCr, serum creatinine; N.D., not determined; a.u., arbitrary units.