Table 1.
Additional transcription factors with defined effects on Pols I and II.
| Pol II | Pol I | |
|---|---|---|
| CSB/Rad26 | CSB plays a role in maintaining and remodeling chromatin [177]. CSB/Rad26 is involved in transcription-coupled nucleotide excision repair, and interacts with stalled Pol II [178–180]. CSB is also important in recruitment of Pol II and its basal TFs to the promoters of housekeeping genes [181]. | CSB promotes efficient rRNA synthesis and recruits the histone methyltransferase G9a to rDNA repeats to activate Pol I transcription [182, 183]. |
| c-Myc | c-myc regulates Pol II transcription elongation [184]. Association of c-myc with P-TEFb contributes to transcriptional pause release of Pol II [185]. | c-Myc can directly activate Pol I transcription, and the effect of c-myc on Pol I transcription is evolutionarily conserved [186–188]. |
| Actin and Myosin | Actin is part of the Pol II pre-initiation complex and stimulates Pol II transcription [189, 190]. Myosin co-localizes with Pol II and affect Pol II transcription as well [191]. | Actin and Myosin positively influence Pol I transcription [192–194]. |
| Reb1/TTF1 | Reb1/TTF1 Reb1 can mediate Pol II transcription termination [195]. | Reb1 mediates Pol I transcription termination [196, 197]. |
| THO | THO complex is required for efficient Pol II elongation through genes containing GC-rich or tandemly repeating DNA sequences [198]. THO is critical for Pol II transcription elongation and associated recombination in vivo and in vitro [199–202] | THO complex positively influences Pol I initiation and elongation [203]. |
| SWI/SNF | The SWI/SNF complex can positively and negatively regulate Pol II transcription via chromatin remodeling [204–207]. | SWI/SNF positively influences the elongation step of Pol I transcription [208]. |
| Spt16 | Spt16 facilitates Pol II transcription through nucleosomes [209]. | Spt16 mediates nucleosome assembly to promote Pol I transcription [210]. |