Table 2.
Linear regression-modeled cross-sectional associations between endogenous estradiol, estrone, and sex hormone-binding globulin levels with hemostatic factor levels in postmenopausal women.
| n | E2 (pg/mL) (n=131) | E1 (pg/mL) (n=131) | SHBG (nmol/L) (n=131) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hormone mean (SD) |
6.5 (6.9) | 27.0 (24.2) | 77.7 (48.2) | ||||||||
| Hemostatic Factor mean (SD) |
Adjusted Average Difference (95% CI)* |
p- value |
Adj. % Diff. in SD† |
Adjusted Average Difference (95% CI)* |
p-value | Adj. % Diff. in SD† |
Adjusted Average Difference (95% CI)* |
p- value |
Adj. % Diff. in SD† |
||
| Thrombin Generation | |||||||||||
| Peak Value (nM) | 131 | 261.1 (54.8) | 0.27 (−0.82, 1.4) | 0.62 | 2.9% | 0.031 (−0.24, 0.30) | 0.82 | 1.4% | 0.082 (−0.079, 0.24) | 0.32 | 7.2% |
| ETP (nMxMin) | 131 | 1214.9 (268.8) | 0.092 (−5.5, 5.7) | 0.97 | 0.23% | −0.23 (−1.4, 0.97) | 0.71 | −2.0% | 0.043 (−0.78, 0.86) | 0.92 | 0.77% |
| Lag-time (min) | 131 | 2.3 (0.63) | −0.0053 (−0.018, 0.0075) | 0.42 | −5.7% | −0.00076 (−0.0041, 0.0026) | 0.66 | −2.9% | −0.00084 (−0.0026, 0.00088) | 0.34 | −6.4% |
| Time-to-peak (min) | 131 | 4.4 (0.87) | −0.0067 (−0.029, 0.015) | 0.55 | −5.3% | −0.0013 (−0.0061, 0.0036) | 0.61 | −3.5% | −0.0020 (−0.0045, 0.00053) | 0.12 | −10.9% |
| nAPCsr | 130 | 1.6 (1.2) | −0.0048 (−0.029, −0.019) | 0.69 | −2.8% | −0.0025 (−0.0073, 0.0023) | 0.30 | -5.1% | 0.00015 (−0.0033, 0.0036) | 0.93 | 0.58% |
| FVIIc (%) | 126 | 131.1 (36.0) | 0.15 (−0.72, 1.02) | 0.74 | 2.8% | 0.034 (−0.22, 0.29) | 0.79 | 2.3% | −0.0074 (−0.15, 0.14) | 0.92 | −0.99% |
| ATc (%) | 124 | 105.8 (13.9) | −0.39 (−0.81, 0.029) | 0.068 | −19.9% | −0.13 (−0.22, −0.039) | 0.0052 | −18.9% | 0.0012 (−0.053, 0.055) | 0.96 | 0.36% |
| PSAg (%) | 130 | 109.5 (18.9) | −0.90 (−1.5, −0.36) | 0.0013 | −32.9% | −0.24 (−0.35, −0.12) | 0.00008 | −30.4% | −0.075 (−0.15, 0.0018) | 0.055 | −19.1% |
Bolded, italicized associations are significant at a multiple comparisons corrected level of p<0.00069. Bolded associations are significant only at a nominal level of p<0.00625.
Adj.=adjusted; ATc=antithrombin activity; CI=confidence interval; E1=estrone; E2=estradiol; ETP=endogenous thrombin potential; FVIIc=factor VII activity; nAPCsr=normalized activated protein C sensitivity ratio; PSAg=total protein S antigen; SD=standard deviation; SHBG=sex hormone binding globulin
Adjusted for linear age, linear BMI, current smoking, treated diabetes, race/ethnicity, prior CVD, surgical menopause, treated hypertension.
Adjusted average % Difference in 1 SD of hemostatic factor, per 1-SD difference in endogenous hormone.