Table 3.

Linear regression-modeled cross-sectional associations between endogenous testosterone levels with hemostatic factor levels in postmenopausal women.

	n		Total T (ng/dL) (n=131)			Free T (ng/dL) (n=131)
		Hormone mean (SD)	15.3 (10.6)			0.17 (0.12)
		Hemostatic Factor mean (SD)	Adjusted Average Difference (95% CI)*	p-value	Adj. % Diff. in SD†	Adjusted Average Difference (95% CI)*	p-value	Adj. % Diff. in SD†
Thrombin Generation
Peak Value (nM)	131	261.1 (54.8)	0.098 (−0.73, 0.93)	0.82	1.9%	−20.2 (−117.5, 77.2)	0.68	−4.4%
ETP (nMxMin)	131	1214.9 (268.8)	1.5 (−4.1, 7.2)	0.59	6.1%	120.2 (−439.4, 679.8)	0.67	5.3%
Lag-time (min)	131	2.3 (0.63)	0.00043 (−0.0073, 0.0081)	0.91	0.72%	0.047 (−0.53, 0.63)	0.87	0.88%
Time-to-peak (min)	131	4.4 (0.87)	0.0011 (−0.012, 0.015)	0.87	1.4%	0.52 (−0.53, 1.6)	0.33	7.0%
nAPCsr	130	1.6 (1.2)	0.0035 (−0.014, 0.021)	0.70	3.1%	−0.59 (−1.7, 1.6)	0.94	−0.58%
FVIIc (%)	126	131.1 (36.0)	−0.21 (−0.84, 0.42)	0.51	−6.2%	−3.1 (−45.3, 39.0)	0.88	-1.0%
ATc (%)	124	105.8 (13.9)	−0.20 (−0.46, 0.048)	0.11	−13.3%	−25.5 (−54.5, 3.5)	0.085	−18.4%
PSAg (%)	130	109.5 (18.9)	−0.29 (−0.53, −0.041)	0.022	−16.2%	−18.4 (−43.4, 6.7)	0.15	−11.5%

Bolded, italicized associations are significant at a multiple comparisons corrected level of p<0.00069. Bolded associations are significant only at a nominal level of p<0.00625.

Adj.=adjusted; ATc=antithrombin activity; CI=confidence interval; ETP=endogenous thrombin potential; FVIIc=factor VII activity; nAPCsr=normalized activated protein C sensitivity ratio; PSAg=total protein S antigen; SD=standard deviation; T=testosterone

^*Adjusted for linear age, linear BMI, current smoking, treated diabetes, race/ethnicity, prior CVD, surgical menopause, treated hypertension.

^†Adjusted average % Difference in 1 SD of hemostatic factor, per 1-SD difference in endogenous hormone.