Table 4.
Linear regression-modeled cross-sectional associations between precursor steroid levels with hemostatic factor levels in postmenopausal women.
| n | DHEAS (ug/mL) (n=131) | DHEA (ng/dL) (n=131) | Androstenedione (ng/dL) (n=131) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hormone mean (SD) | 0.52 (0.46) | 110.2 (82.5) | 35.8 (19.1) | ||||||||
| Hemostatic Factor mean (SD) | Adjusted Average Difference (95% CI)* | p-value | Adj. % Diff. in SD† | Adjusted Average Difference (95% CI)* | p-value | Adj. % Diff. in SD† | Adjusted Average Difference (95% CI)* | p-value | Adj. % Diff. in SD† | ||
| Thrombin Generation | |||||||||||
| Peak Value (nM) | 131 | 261.1 (54.8) | −40.8 (−59.5, −22.2) | 0.000031 | −34.2% | −0.17 (−0.31, −0.034) | 0.015 | −25.3% | −0.29 (−0.88, 0.30) | 0.34 | −10.1% |
| ETP (nMxMin) | 131 | 1214.9 (268.8) | −140.7 (−212.1, −69.4) | 0.00016 | −24.0% | −0.66 (−1.2, −0.12) | 0.018 | −20.3% | −1.03 (−3.5, 1.4) | 0.41 | −7.3% |
| Lag-time (min) | 131 | 2.3 (0.63) | −0.067 (−0.23, 0.10) | 0.43 | −4.8% | −0.00017 (−0.0013, 0.00091) | 0.75 | −0.56% | 0.0022 (−0.0033, 0.0077) | 0.43 | 6.6% |
| Time-to-peak (min) | 131 | 4.4 (0.87) | 0.23 (−0.084, 0.53) | 0.15 | 11.9% | 0.00091 (−0.0011, 0.0029) | 0.38 | 8.0% | 0.0048 (−0.0031, 0.013) | 0.23 | 10.5% |
| nAPCsr | 130 | 1.6 (1.2) | −0.89 (−1.4, −0.34) | 0.0018 | −34.0% | −0.0034 (−0.0064, −0.00047) | 0.024 | −21.8% | −0.0064 (−0.017, 0.0041) | 0.23 | −10.3% |
| Factor VII (%) | 126 | 131.1 (36.0) | −1.15 (−10.8, 8.5) | 0.81 | −1.5% | −0.078 (−0.14, −0.018) | 0.011 | −18.6% | −0.043 (−0.40, 0.31) | 0.81 | −2.3% |
| ATc (%) | 124 | 105.8 (13.9) | 0.53 (−4.7, 5.8) | 0.84 | 1.5% | 0.0028 (−0.031, 0.037) | 0.87 | 2.6% | 0.0057 (−0.14, 0.14) | 0.94 | 0.66% |
| PSAg (%) | 130 | 109.5 (18.9) | −6.9 (−14.0, 0.12) | 0.054 | −16.9% | −0.065 (−0.11, −0.021) | 0.004 | −27.2% | −0.14 (−0.34, 0.063) | 0.17 | −14.2% |
Bolded, italicized associations are significant at a multiple comparisons corrected level of p<0.00069. Bolded associations are significant only at a nominal level of p<0.00625.
Adj.=adjusted; ATc=antithrombin activity; CI=confidence interval; DHEAS=dehydroepiandrosterone-sulfate; DHEA=dehydroepiandrosterone; ETP=endogenous thrombin potential; FVIIc=factor VII activity; nAPCsr=normalized activated protein C sensitivity ratio; PSAg=total protein S antigen; SD=standard deviation
Adjusted for linear age, linear BMI, current smoking, treated diabetes, race/ethnicity, prior CVD, surgical menopause, treated hypertension.
Adjusted average % Difference in 1 SD of hemostatic factor, per 1-SD difference in endogenous hormone.