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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Clin Exp Allergy. 2017 Jan 11;47(2):224–235. doi: 10.1111/cea.12866

Figure 2.

Figure 2

Regulation of allergic inflammation by ROCK2. Bronchoalveolar lavage (BAL) lymphocytes (A), IL-13 (B), IL-5 (C), eosinophils (D), eotaxin (E), and mast-cell tryptase 1 (MCPT1) (a marker of mast-cell degranulation) (F) were assessed in WT and ROCK2+/- mice that were sensitized with OVA and challenged with either aerosolized OVA or PBS. WT mice were treated with saline and ROCK2+/- mice were treated with either saline (SAL) or splenic CD4+ cells from OT-II mice (CD4+) as described in Fig.1A. BAL was performed 48 h after the last challenge. Results are mean ± SEM of data from 8-19 mice per group. * p<0.05 versus PBS in mice with same genotype and treatment; + p<0.05 versus WT mice; and # p<0.05 versus ROCK2+/- mice treated with saline.