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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Clin Exp Allergy. 2017 Jan 11;47(2):224–235. doi: 10.1111/cea.12866

Figure 4.

Figure 4

Regulation of goblet cell hyperplasia by ROCK2. (A) PAS+ cell density (expressed as the number of PAS+ cells per 100 um of basement membrane) quantified morphometrically and (B) pulmonary mRNA abundance of Muc5ac and in WT and ROCK2+/- mice that were sensitized with OVA and challenged with either aerosolized OVA or PBS. WT mice were treated with saline and ROCK2+/- mice were treated with either saline (SAL) or splenic CD4+ cells from OT-II mice (CD4+) as described in Fig.1A. Results are mean ± SEM of 3 PBS challenged mice per group and 6-7 OVA challenged mice per group. * p<0.05 versus PBS in mice with same genotype and treatment and # p<0.05 versus WT.