Table 2.

Odds Ratio of Any Stroke Symptom by Biomarker Quartiles and per SD Increment of Each Biomarker

	Odds Ratio of Any Stroke Symptom by Biomarker Quartiles (reference group is Quartile 1)*			Odds Ratio of Any Stroke Symptom per SD Higher Biomarker
	Quartile 2	Quartile 3	Quartile 4
Cardiac Function
NT-proBNP, pg/mL
Model 1	1.87 (1.08, 3.23)	1.77 (1.01, 3.10)	3.06 (1.76, 5.34)	1.54 (1.31, 1.80)
Model 2	1.75 (0.96, 3.17)	1.48 (0.79, 2.77)	2.69 (1.45, 4.98)	1.50 (1.26, 1.80)
Inflammation
Fibrinogen, mg/dL
Model 1	0.87 (0.54, 1.41)	0.96 (0.59, 1.55)	1.24 (0.79, 1.94)	1.11 (0.93, 1.31)
Model 2	0.82 (0.48, 1.40)	0.81 (0.48, 1.36)	1.15 (0.71, 1.87)	1.05 (0.87, 1.26)
CRP, mg/L
Model 1	2.10 (1.27, 3.46)	1.82 (1.10, 3.00)	2.32 (1.43, 3.74)	1.21 (1.04, 1.40)
Model 2	1.91 (1.10, 3.30)	1.55 (0.90, 2.68)	2.16 (1.28, 3.67)	1.20 (1.02, 1.42)
Coagulation
FVIII, %
Model 1	1.04 (0.64, 1.70)	0.99 (0.62, 1.59)	1.14 (0.71, 1.81)	1.03 (0.88, 1.20)
Model 2	1.01 (0.59, 1.73)	0.85 (0.51, 1.43)	0.94 (0.57, 1.55)	0.93 (0.79, 1.09)
FXI, %
Model 1	0.90 (0.55, 1.43)	1.45 (0.92, 2.29)	1.57 (0.99, 2.47)	1.26 (1.07, 1.47)
Model 2	0.94 (0.56, 1.57)	1.52 (0.92, 2.53)	1.59 (0.96, 2.65)	1.24 (1.04, 1.47)
D-dimer, μg/mL
Model 1	1.80 (1.06, 3.04)	1.27 (0.74, 2.16)	1.99 (1.20, 3.29)	1.21 (1.02, 1.42)
Model 2	2.21 (1.23, 3.96)	1.58 (0.86, 2.90)	2.23 (1.26, 3.95)	1.18 (0.98, 1.41)

Model 1 Adjusted for age, race and sex.

Model 2 Adjusted for age, race, sex, history of heart disease, atrial fibrillation, diabetes mellitus, antihypertensive medication use, current smoking, systolic blood pressure, LVH, lipid lowering medication use and regular aspirin use.

^*Quartile cutpoints (25^th, 50^th, 75^th percentile) and SD values: NT-proBNP (31, 61, 121 pg/ml and 1.11*), Fibrinogen (334, 384, 446 and 99 mg/dL), FVIII (90, 109, 137% and 0.33*), FXI (90, 103, 122% and 0.25*), CRP (0.9, 2.1, 4.7 mg/dL and 1.1*), D-dimer (0.23, 0.39, 0.71 pg/ml and 0.85*) *=Log-transformed