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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Thromb Haemost. 2016 Nov 8;15(1):98–109. doi: 10.1111/jth.13436

Fig. 1. Characterization of novel transgenic mouse model expressing supratherapeutic levels of 2bF8 on FVIIInull background (LV17/18tg mice).

Fig. 1

FVIII:C in platelet lysates from WT mice (n = 6), and homozygous LV17tg (n = 8), LV18tg (n = 10), and LV17/18tg (n = 6) mice, and from 2bF8trans mice (n = 8) determined by chromogenic FVIII:C assay. LV17/18tg mice expressed 30-fold greater levels of FVIII in platelets than 2bF8trans mice in which hemostasis on an endogenous FVIII-deficient background was restored.