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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Thromb Haemost. 2016 Nov 8;15(1):98–109. doi: 10.1111/jth.13436

Fig. 3. Impact of supratherapeutic levels of 2bF8 on thrombosis risk during inflammation.

Fig. 3

WT or LV17/18tg mice were challenged intraperitoneally with 40 mg kg−1 LPS or injected with PBS as control. Samples were collected after 16 hours and (A) hematocrit (HCT) and (B) platelet counts were assessed on an animal blood counter. (C) Fibrinogen levels, (D) D-Dimer levels, and (E) TAT levels were determined by ELISA. ***P < 0.001(Student’s t-test). Compared with PBS treated animals, LPS challenge increased fibrinogen levels 1.6 and 1.3-fold, D-Dimer levels 14.7 and 8.0-fold and TAT levels 3.3 and 2.2-fold in WT and LV17/18tg mice, respectively. (F) Fibrin deposition in the livers of indicated mice was evaluated by immunohistochemistry. Representative images from 1 of 3 mice per group are shown.