Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Impaired Nrf2 signaling in AMD. Oxidative stress with reactive oxygen species (ROS) induce Nrf2 production and release from Keap1 with transit to the nucleus. After binding to antioxidant response elements in the promoters of antioxidant and cytoprotective genes with Maf proteins, antioxidant genes are upregulated. With aging and chronic oxidative stress, Nrf2 production and activity is reduced, and the antioxidant response is impaired, which contributes to RPE dysfunction.
