Table 1.
Parameters | High dose chemotherapy + autologous stem cell transplant | Conventional chemotherapya | ||
---|---|---|---|---|
Base valueb | Source | Base value | Source | |
Overall survival (median in months) | ||||
ISS Stage I | 67 | Kumar et al. [18] | 58.8 | Ludwig et al. [19] |
ISS Stage II | 79 | 42 | ||
ISS Stage III | 20 | 26.4 | ||
Progression free survival (median in months) | ||||
ISS Stage I | 32 | Kumar et al. [18] | 24 | Primary analysis of PGI Data |
ISS Stage II | 75 | 18 | ||
ISS Stage III | 16 | 12 |
aConventional chemotherapy refers to Melphalan and Prednisone regimen
bBase value represent epidemiological parameters based on extensive review of literature, used in the model to form part of our base case analysis