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. 2017 Jan 30;3:16107. doi: 10.1038/cddiscovery.2016.107

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effects of IAPP on the expression of PI3K/AKT-mTOR and p38/JNK MAPK signaling. (a) Western blot analysis revealed the phosphorylated and unphosphorylated protein levels of PI3K/AKT-mTOR signaling pathway. (b) Western blot analysis revealed the phosphorylated and unphosphorylated protein levels of P38 and JNK. (c–e) Statistical analysis of the ratio of P-PI3k/PI3K (c), p-AKT/AKT (d), and p-mTOR/mTOR (e) in different groups, including NC, pLV-veh, pLV-IAPP, Ctrl siIAPP, pLV-siIAPP, and Pramlintide. (f–h). Statistical analysis of the ratio of P-P38/P38 (f), p-JNK1/JNK1(g), p-JNK2/JNK2 (h) in different groups. Data are representative of three independent experiments, and P-values are shown: *P<0.05; **P<0.01.