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AAV2-miSyn4 decreases α-synuclein in Thy1-SNCA mice after 90 days. (A) Injection of AAV2-miSyn4 into the substantia nigra decreased hSNCA immunoreactivity using a human-specific synuclein antibody, (B) qPCR of α-synuclein from Thy1-SNCA mice revealed significantly less α-synuclein in mice injected with AAV2-miSyn4 in both the substantia nigra and the cerebral cortex. Sample size as shown; *p < 0.05 by t-test.
