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ROCK inhibition with Fasudil stabilizes motor performance in SOD1G93A male mice. Displayed are mean durations on the rotarod of female (Fas30 n = 14, Fas100 n = 15, Veh n = 14) (A) and male (Fas30 n = 11, Fas100 n = 12, Veh n = 12). (B) SOD1 G93A mice treated with 30 mg/kg Fasudil (Fas30), 100 mg/kg Fasudil (Fas100), or with vehicle (Veh). Data represent means ± SEM. * P < 0.05; **P < 0.01, ***P < 0.001.
