Table 4.
MBL2 polymorphism, distribution, and comparison of genotypes and alleles in RVVI types with control group.
| No. (%) of Controls | No. (%) of RVVI clinical categories | Genotypic and allelic comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls (N = 203) | BV (N = 97) | VVC (N = 62) | MI (N = 41) | BV vs. Controls | VVC vs. Controls | MI vs. Controls | ||||
| OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |||||
| rs1003125 | ||||||||||
| Genotypes | ||||||||||
| LL | 52 (25.61) | 17 (17.5) | 19 (30.64) | 8 (19.51) | 1 | 1 | 1 | |||
| LH | 132 (65.02) | 66 (68.04) | 37 (59.6) | 30 (73.17) | 1.52 (0.82–2.84) | 0.18 | 0.76 (0.40–1.45) | 0.41 | 1.47 (0.63–3.43) | 0.36 |
| HH | 19 (9.359) | 14 (14.4) | 6 (9.67) | 3 (7.31) | 2.25 (0.93–5.44) | 0.07 | 0.86 (0.30–2.48) | 0.78 | 1.02 (0.24–4.27) | 0.97 |
| Alleles | ||||||||||
| L | 236 (58.128) | 100 (51.5) | 75 (60.48) | 46 (56.09) | 1 | 1 | 1 | |||
| H | 170 (41.87) | 94 (48.4) | 49 (39.51) | 36 (43.90) | 1.30 (0.92–1.84) | 0.12 | 0.90 (0.60–1.36) | 0.64 | 1.08 (0.67–1.75) | 0.73 |
| rs7096206 | ||||||||||
| Genotypes | ||||||||||
| YY | 102 (50.2) | 23 (23.71) | 21 (33.87) | 12 (29.26) | 1 | 1 | 1 | |||
| YX | 86 (42.3) | 65 (67.01) | 35 (56.45) | 21 (51.21) | 3.35 (1.92–5.84) | <0.0001*** | 1.97 (1.07–3.64) | 0.02* | 2.07 (0.96–4.46) | 0.06 |
| XX | 15 (7.38) | 9 (9.27) | 6 (9.67) | 8 (19.51) | 2.66 (1.03–6.82) | 0.04* | 1.94 (0.67–5.59) | 0.21 | 4.53 (1.59–12.90) | 0.004** |
| Alleles | ||||||||||
| Y | 290 (71.4) | 111 (57.21) | 77 (62.09) | 45 (54.87) | 1 | 1 | 1 | |||
| X | 116 (28.57) | 83 (42.78) | 47 (37.90) | 37 (90.24) | 1.86 (1.30–2.67) | 0.0006*** | 1.52 (1.00–2.32) | 0.04* | 2.05 (1.26–3.33) | 0.003** |
| rs7095891 | ||||||||||
| Genotypes | ||||||||||
| PP | 2 (0.985) | 0 | 1 (1.61) | 4 (9.75) | – | NA | 1 | 1 | ||
| PQ | 196 (96.55) | 96 (98.96) | 61 (98.38) | 37 (90.24) | 1 | 0.62 (0.05–6.98) | 0.7 | 0.09 (0.01–0.53) | 0.007** | |
| 5 (2.46) | 1 (1.03) | 0 | 0 | 0.40 (0.04–3.54) | 0.41 | – | NA | – | NA | |
| Alleles | ||||||||||
| P | 200 (49.26) | 96 (49.48) | 63 (50.80) | 45 (54.87) | 1 | 1 | 1 | |||
| Q | 206 (50.73) | 98 (50.51) | 61 (49.19) | 37 (45.12) | 0.99 (0.70–1.39) | 0.95 | 0.94 (0.62–1.40) | 0.76 | 0.79 (0.49–1.28) | 0.35 |
| rs1800450 | ||||||||||
| Genotypes | ||||||||||
| AA | 1 (0.49) | 1 (1.03) | 0 (0) | 0 (0) | – | NA | – | NA | – | NA |
| AB | 200 (98.52) | 96 (98.9) | 62 (100) | 41 (100) | – | NA | – | NA | – | NA |
| BB | 2 (0.98) | 0 (0) | 0 (0) | 0 (0) | – | NA | – | NA | – | NA |
| Alleles | ||||||||||
| A | 202 (49.75) | 98 (50.5) | 62 (50) | 41 (50) | 1 | 1 | 1 | |||
| B | 204 (50.24) | 96 (49.4) | 62 (50) | 41 (50) | 0.97 (0.68–1.36) | 0.86 | 0.99 (0.66–1.48) | 0.96 | 0.99 (0.61–1.59) | 0.96 |
OR, Odds Ratio; CI, Confidence Intervals,
*
indicates significant p-values (p < 0.05),
**
indicates high significant values (p < 0.01),
***
indicates highly significant values (p < 0.001).