Table 1.
– Bypassing of the blood–brain barrier (the target organ is directly reached) |
– Higher drug concentration in the inner ear |
– Avoiding “first-pass” effects |
– Reduction of adverse systemic effects |
– Lower drug doses are necessary |
– Bypassing of the blood–brain barrier (the target organ is directly reached) |
– Higher drug concentration in the inner ear |
– Avoiding “first-pass” effects |
– Reduction of adverse systemic effects |
– Lower drug doses are necessary |