Table 3.

Open questions related to drug delivery in combination with cochlear implants

– Which drugs are useful?

– Which strategy of delivery is appropriate: systemic, locally intratympanic, locally intracochlear, or directly via the implant?

– Which time of application is reasonable in the context of extracochlear and systemic therapy: before, during, or after CI implantation?

– Which formulation and which carrier should be used?

– Which delivery system should be applied?

– Which dose should be applied?

– What are the pharmacokinetic characteristics?

– What is the additional benefit of additional drug application?

– What is the risk–benefit ratio?