Table 2.
Relation between clinicopathological features and immunohistochemical markers in the 50 patients with TCC of bladder.
| Characteristics | All | NEDD9 | p | P38 | p | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low (N = 17) | High (N = 33) | Low (N = 28) | High (N = 22) | |||||||||
| (N = 50) | ||||||||||||
| Number | (%) | Number | (%) | Number | (%) | Number | (%) | Number | (%) | |||
| Age (years) | ||||||||||||
| Mean ± SD | 55.08 ± 10.3 | 55.29 ± 12.3 | 54.96 | ±9.37 | 0.766‡ | 51.7 ± 10.265 | 59.3 ± 9.031 | 0.013‡ | ||||
| Median (range) | 52 | (35–75) | 56 | (35–72) | 50 | (43–75) | 49 | (35–72) | 61 | (43–75) | ||
| ≤60 years | 32 | (64%) | 10 | (58.8%) | 22 | (66.7%) | 0.584§ | 21 | (75%) | 11 | (50%) | 0.068§ |
| >60 years | 18 | (36%) | 7 | (41.2%) | 11 | (33.3%) | 7 | (25%) | 11 | (50%) | ||
|
| ||||||||||||
| Sex | ||||||||||||
| Male | 35 | (70%) | 5 | (29.4%) | 30 | (90.9%) | <0.001§ | 13 | (46.4%) | 22 | (100%) | <0.001§ |
| Female | 15 | (30%) | 12 | (70.6%) | 3 | (9.1%) | 15 | (53.6%) | 0 | (0%) | ||
|
| ||||||||||||
| Size (cm) | ||||||||||||
| Mean ± SD | 3.74 ± 2.7 | 2.35 ± 1.4 | 4.4 ± 2.05 | 0.015‡ | 2.89 | ±2.42 | 4.8 ± 2.8 | 0.010‡ | ||||
| Median (range) | 2 | (1–10) | 2 | (1–6) | 2.9 | (1–10) | 2 | (1–10) | 6 | (1–9) | ||
| ≤5 cm | 34 | (68%) | 16 | (94.1%) | 18 | (54.5%) | 0.004§ | 24 | (85.7%) | 10 | (45.5%) | 0.002§ |
| >5 cm | 16 | (32%) | 1 | (5.9%) | 15 | (45.5%) | 4 | (14.3%) | 12 | (54.5%) | ||
|
| ||||||||||||
| Multiplicity | ||||||||||||
| Absent | 17 | (34%) | 17 | (100%) | 0 | (0%) | <0.001§ | 14 | (50%) | 3 | (13.6%) | 0.007§ |
| Present | 33 | (66%) | 0 | (0%) | 33 | (100%) | 14 | (50%) | 19 | (86.4%) | ||
|
| ||||||||||||
| Grade | ||||||||||||
| Low grade | 13 | (26%) | 13 | (76.5%) | 0 | (0%) | <0.001§ | 13 | (46.4%) | 0 | (0%) | <0.001§ |
| High grade | 37 | (74%) | 4 | (23.5%) | 33 | (100%) | 15 | (53.6%) | 22 | (100%) | ||
|
| ||||||||||||
| Deep invasion | ||||||||||||
| Absent | 24 | (48%) | 16 | (94.1%) | 8 | (24.2%) | <0.001§ | 22 | (78.6%) | 2 | (9.1%) | <0.001§ |
| Present | 26 | (52%) | 1 | (5.9%) | 25 | (75.8%) | 6 | (21.4%) | 20 | (90.9%) | ||
|
| ||||||||||||
| T | ||||||||||||
| Ta | 5 | (10%) | 5 | (29.4%) | 0 | (0%) | <0.001∗ | 5 | (17.9%) | 0 | (0%) | <0.001∗ |
| T1 | 19 | (38%) | 11 | (64.7%) | 8 | (24.2%) | 17 | (60.7%) | 2 | (9.1%) | ||
| T2 | 22 | (44%) | 1 | (5.9%) | 21 | (63.6%) | 6 | (21.4%) | 16 | (72.7%) | ||
| T3 | 4 | (8%) | 0 | (0%) | 4 | (12.1%) | 0 | (0%) | 4 | (18.2%) | ||
|
| ||||||||||||
| Lymph node | ||||||||||||
| Negative | 36 | (72%) | 16 | (94.1%) | 20 | (60.6%) | 0.018§ | 27 | (96.4%) | 9 | (40.9%) | <0.001§ |
| Positive | 14 | (28%) | 1 | (5.9%) | 13 | (39.4%) | 1 | (3.6%) | 13 | (59.1%) | ||
|
| ||||||||||||
| NEDD9 | ||||||||||||
| Mean ± SD | 34.54 | ±24.15 | 8.64 | ±4.83 | 47.87 | ±18.49 | <0.001‡ | 26.85 | ±24.43 | 44.31 | ±20.37 | 0.005‡ |
| Median (range) | 30 | (3–90) | 7 | (3–20) | 50 | (20–90) | 20 | (3–90) | 50 | (5–80) | ||
| Low | 17 | (34%) | 14 | (50%) | 3 | (13.6%) | 0.007§ | |||||
| High | 33 | (66%) | 14 | (50%) | 19 | (86.4%) | ||||||
|
| ||||||||||||
| P38 | ||||||||||||
| Mean ± SD | 44.1 ± 28.1 | 30.2 ± 24.7 | 51.2 ± 27.5 | 0.016‡ | 20.5 ± 7.24 | 74.09 ± 10.07 | <0.001‡ | |||||
| Median (range) | 30 | (10–90) | 20 | (10–90) | 60 | (10–90) | 20 | (10–35) | 70 | (60–90) | ||
| Low | 28 | (56%) | 14 | (82.4%) | 14 | (42.4%) | 0.007§ | |||||
| High | 22 | (44%) | 3 | (17.6%) | 19 | (57.6%) | ||||||
Categorical variables were expressed as number (percentage); continuous variables were expressed as mean ± SD and median (range).
‡Mann–Whitney U test; §Chi-square test; ∗Chi-square test for trend; p < 0.05 is significant.