Table 4.
Diagnostic performance of immunohistochemical markers as a predictor for deep invasion of TCC.
| Markers | TP No (%) |
FP No (%) |
TN No (%) |
FN No (%) |
SN% (95% CI) |
SP% (95% CI) |
PPV% (95% CI) |
NPV% (95% CI) |
Accuracy (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| NEDD9 | 25 (50%) | 8 (16%) | 16 (32%) | 1 (2%) | 96.2% (88.8–100) | 66.7% (47.8–85.5) | 75.8% (61.1–90.4) | 94.1% (82.9–100) | 82% (71.4–92.6) |
| P38 | 20 (40%) | 2 (4%) | 22 (44%) | 6 (12%) | 76.9% (60.7–93.1) | 91.7% (80.6–100) | 90.9% (78.9–100) | 78.6% (63.4–93.8) | 84% (73.8–94.2) |
| NEDD9 & P38 | 19 (38%) | 0 (0%) | 27 (52%) | 7 (14%) | 73.1% (56–90.1) | 100% | 100% | 79.4% (65.8–93) | 86% (76.7–95.3) |
TP: true positive; FP: false positive; TN: true negative; FN: false negative; SN: sensitivity; SP: specificity; PPV: positive predictive value; NPV: negative predictive value, 95% CI: 95% confidence interval; p < 0.05 is significant.