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The Wnt/β-catenin pathway was stimulated by either treatment of LiCl or BIO. Cells were cultured in complete medium with LiCl (20 mM) or BIO (5 nM) and exposed to hypoxic conditions for 3 days. The expression of LEF-1 and Axin2 was measured by RT-qPCR. (a)–(d) Either LiCl or BIO increased the RNA levels of LEF-1 and Axin2, which suggested stimulation of the Wnt/β-catenin pathway. ∗∗p < 0.01; ∗∗∗p < 0.001; n = 3. Data are represented as mean ± SD.
