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. 2017 Jan 31;5:16049. doi: 10.1038/boneres.2016.49

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Copyright © 2017 The Author(s)

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Dmp1-Cre Bmpr1a^f/f mice develop intestinal polyps. (a–d) H&E staining of cross-sections through small (a,b) or large intestines (c,d) of control (Bmpr1a^f/f) (a,c) or CKO (Dmp1-Cre; Bmpr1a^f/f) (b,d) littermate mice. Yellow arrowheads in b denote fusing and blunting of villi. (a’–d’) Higher-magnification images of boxed areas in (a–d), respectively, showing a polyp in small (b’) or large (d’) intestine. Yellow bracket in (b’) denotes a pocket of proliferating epithelial cells stained brown for BrdU labeling. H&E, hematoxylin and eosin.