Figure 1.

Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) increases in an age dependent manner in brains of PS2APP mice. (A) Post mortem levels of sTREM2 were quantified by ELISA from forebrain tissue at indicated time-points (n = 4–8 mice per group). (B) Forebrain in vivo glial activation assessed by 18-kDA translocator protein (TSPO) [¹⁸F]-GE180 μPET is presented as standard-uptake-value-ratios (SUVR) relative to white matter reference tissue uptake (n = 8 mice per group). (C) Post mortem levels of total β-amyloid peptide (Aβ) were quantified by ELISA from forebrain tissue at indicated time-points (n = 4–8 mice per group). (D) Forebrain in vivo amyloidosis assessed by [¹⁸F]-florbetaben μPET is presented as SUVR relative to white matter reference tissue uptake (n = 8 mice per group). Data information: in (A–D), data are presented as mean ± SD. *significant differences in PS2APP mice vs. their 5 month old littermates (*p < 0.05; **p < 0.001); ^#significant differences in PS2APP mice vs. age-matched wild-type (WT; ^#p < 0.05; ^##p < 0.001); °significant differences between young and aged WT (°p < 0.05). Analysis of variance (ANOVA) with Tukey post hoc applies for all. Please note that data of (B,D) were partially previously published (Brendel et al., 2016).