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. 2017 Jan 31;7:41476. doi: 10.1038/srep41476

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(A) Representative action potentials (APs) recorded with current-clamp in a ventricular myocyte under control conditions (black) and with an increasing concentration of phenanthrene (pink/red traces). (B) Means ± SEM (n = 9, N = 5) of action potential duration (APD) at 10, 50 and 90% repolarization and (C) AP triangulation (calculated as APD₉₀ − APD₃₀) before and after phenanthrene exposure. (D) Reduction in the delayed rectifier K⁺ channel current (I_Kr) density recorded with voltage-clamp under control conditions (black) and with an increasing concentration of phenanthrene (pink/red traces) or with the I_Kr specific blocker E4031 (gray trace). (E) Means ± SEM of peak I_Kr tail in control (black bar) and with an increasing concentration of phenanthrene (pink/red bars, n = 7, N = 3). (F) Change in I_Kr tail (expressed as a percentage of control) in response to phenanthrene. *Indicates significant difference (P < 0.05, one-way ANOVA).