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. 2017 Jan 31;7:41756. doi: 10.1038/srep41756

Figure 3. Rejuvenation of BM-derived cardiac resident Sca-1+ cells associated with improved healing of aged heart.

Figure 3

The left anterior coronary artery of Sca-1+ [(YSca1+)-O] and Sca-1− [(YSca1−)-O] chimeric mice and aged control (Old) mice was ligated 12 weeks after bone marrow reconstitution. Ventricular function was evaluated by serial echocardiography (n = 5–6/group) 4 weeks post-myocardial infarction (MI) with fractional shortening (A). (B) Representative pressure-volume (P-V) loops from each of the three groups. Invasive haemodynamic measurements (n = 4–6/group) taken 4 weeks post-MI were used to calculate load-dependent indices of ventricular function, including ejection fraction (C). Load-independent indices including end-systolic elastance [Ese] (D) and preload recruited stroke work [PRSW] (E) were also measured. Representative whole hearts sectioned transversely at the mid-papillary muscle level (F) were used to quantify scar area (G) and thickness (H, n = 5–6/group) 4 weeks post–MI. *p < 0.05, **p < 0.01. LAD: ligation of left anterior coronary artery. Data analysis used one- way repeated-measures ANOVA followed by Bonferroni post-hoc tests for multiple comparisons (A) and one-way ANOVA followed by Tukey post-hoc tests to evaluate differences among groups (C,D,E,G,H). Data shown are mean ± SEM.