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. 2017 Jan 31;7:41835. doi: 10.1038/srep41835

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) Global protein interaction networks centred on RD gene products. Integrative literature based ‘omics’ protein-protein interaction networks for monogenic non-syndromic (M-NS), monogenic syndromic (M-S), and AMD-related disease gene products. The networks were retrieved from the HIPPIE database (http://cbdm.mdc-berlin.de/tools/hippie) and displayed using Cytoscape. (b) Association of proteins to different pathways based on the HPD database. Network representation of between the 208 RD proteins (round rectangles) and the number pathways a particular protein participates (black hexagons with white number inside indicating the number of pathways). The size of the hexagons correlates with the number of pathways a protein is associated to (see legend).