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. 2017 Jan 31;7:41626. doi: 10.1038/srep41626

Figure 1. Interactions and Domain Structure of Sgt1 and Skp1.

Figure 1

(A) Sgt1 recruits Hsp90 function to Leucine Rich Repeat (LRR)-containing proteins. A subset of LRR proteins contain an F-box motif (FBXL proteins) and in these cases Skp1 also interacts with Sgt1. (B) Domain structure of Sgt1 and Skp1 with each domain labeled by its structural fold. The individual helices of the TPR motifs within the Sgt1 TPR domain are labeled. The crystallised complex is highlighted in a blue box. An unconserved loop in S. cerevisiae Skp1 from residues 36–64 is shown as a dashed yellow line. Known interaction partners are listed below the domain with which they associate.