Table 1. Types of natural and induced mutations or polymorphisms and their detection methods.

Source of Mutation	Agent/cause	Effect of Mutation	Mutation Detection Technique	Remarks	References
Natural
	Diverse	Point mutation	EcoTILLING, GBS, RAD		[37-39]
	Diverse	INDELs	AFLP, SSR		[35, 85]
Induced
Random mutation	Chemicals (EMS, NaN3, MNU, ENU)	Point mutation	Mutmap, Map-based	Forward-genetics	[40]
	Chemical or physical	Point mutation	TILLING	Reverse genetics	[19]
	Ionizing radiation (x-ray, gamma-ray	DNA strand breakage
	Fast neutron	Large DNA damage	Deleteagene		[17]
	Non-ionizing radiation (UV)	Pyrimidine dimer
	Insertional mutagenesis (T-DNA)		TAIL-PCR		[41]
Targeted mutation (Genome editing)	Meganuclease	DSB & repair			[21]
	ZFN	DSB & repair			[22, 23]
	TALEN	DSB & repair			[24, 25]
	CRISPR/Cas9	DSB & repair			[26-28]