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Recommended dose for posaconazole in renal and liver impairment patients [12]
| Population | Posaconazole dose adjustment |
|---|---|
| Renal impairment | |
| Creatinine clearance 20-80 ml/min | No adjustment necessary |
| Creatinine clearance < 20 ml/min | No adjustment necessary, monitor for breakthrough fungal infections due to variability in exposure |
| Hepatic impairment | |
| Child-Pugh A, B, C | No adjustment necessary |
