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. 2017 Jan 20;130(2):187–198. doi: 10.4103/0366-6999.198001

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Copyright: © 2017 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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MDL28170 effectively inhibits the expression of TNF-α, iNOS and ICAM-1 and MPO activity. (a, b, and c) the results were quantified and are shown as the mean ± SD, normalized to the ratio of the TNF-α, iNOS, and ICAM-1 band to the β-actin band of the sham group as unity. (d) The bar graphs reflect MPO activity in the injured hemisphere at 6 h and 24 h after CCI. *P < 0.05 compared with the sham group. †P < 0.05 compared with the vehicle group. TNF-α: Tumor necrosis factor-α; iNOS: Inducible nitric oxide synthase; ICAM-1: Intracellular adhesion molecule-1; MPO: Myeloperoxidase; CCI: Controlled cortical impact; SD: Standard deviation.