Figure 4.

The effects of MDL28170 on the levels of MMP-9, occludin, laminin, and TJ. (a, c, and e) Representative Western blots of MMP-9, occludin, laminin, and β-actin; (b, d, and f) the results of the MMP-9, occludin, and laminin band were quantified and are shown as the mean ± SD. *P < 0.05 compared with the sham group. †P < 0.05 compared with the vehicle group. (g) Representative electron micrographs showing the TJ and basement membrane (original magnification: ×80,000 or ×40,000). The TJ is indicated by black arrowheads. The gray arrowhead indicates the damaged structure of the basement membrane. MMP-9: Matrix metalloproteinase-9; TJ: Tight junction.