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. 2017 Jan 20;130(2):187–198. doi: 10.4103/0366-6999.198001

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Copyright: © 2017 Chinese Medical Journal

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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MDL28170 decreases the NSS and contusion volume after CCI in mice and lessens the EBD and water contents of the injured tissue. Vehicle or MDL28170 was injected i.p. at 5 min, 3 h, and 6 h after CCI. The data are expressed as the mean ± SD; n = 8 per group. (a) Effects of MDL28170 on NSS. (b) The bar graph presents the contusion volumes in each group determined by H and E staining. (c) EBD content. (d) Water content. *P <0.05 compared with the sham group. ^†P < 0.05 compared with the vehicle group. NSS: Neurological severity score; EBD: Evans blue dye; CCI: Controlled cortical impact; SD: Standard deviation.