Table 1.
Demographics of the two sample sets in this study
| CT | AD | P-value | |
|---|---|---|---|
| ROW discovery set | |||
| N | 18 | 27 | - |
| AAD, yr | 76.3 ± 7.1 | 84.5 ± 8.0 | 0.001a |
| Gender, % (F : M) | 27.8 : 72.2 | 63.0 : 37.0 | 0.033b |
| PMI, hr | 9.6 ± 9.4 | 13.4 ± 11.6 | 0.158a |
| BW, g | 1268 ± 127 | 1156 ± 120 | 0.003a |
| RIN | |||
| TC | 7.9 ± 0.8 | 7.1 ± 1.2 | 0.006a |
| Hemolysis ratio | |||
| Serum | 1.9 ± 0.6 | 1.7 ± 0.5 | 0.105a |
| APOE | |||
| Genotype, % (ε3*3 : ε3*4 : ε4*4) | 55.6 : 44.4 : 0.0 | 44.4 : 25.9 : 29.6 | 0.550c |
| Allele, % (ε3 : ε4) | 77.8 : 22.2 | 57.4 : 42.6 | 0.069c |
| NIG validation set | |||
| N | 22 | 36 | - |
| AAE, yr | 73.7 ± 8.4 | 74.7 ± 7.3 | 0.556a |
| Gender, % (F : M) | 80.0 : 20.0 | 63.9 : 36.1 | 0.333b |
| MMSE | 29.3 ± 0.7 | 19.3 ± 5.4 | 4.8.E-08a |
| Hemolysis ratio | |||
| Serum | 1.3 ± 0.2 | 1.3 ± 0.2 | 0.316a |
| APOE | |||
| Genotype, % (ε3*3 : ε3*4) | 85.7 : 14.3 | 55.6 : 44.4 | 0.056c |
| Allele, % (ε3 : ε4) | 92.9 : 7.1 | 77.8 : 22.2 | 0.090c |
Abbreviations: AAD age at death, AAE age at examination, AD Alzheimer’s disease, APOE apolipoprotein E, BW brain weight, CT control, F female, g grams, hr hours, M male, MMSE mini-mental state examination, PMI postmortem interval, RIN RNA integrity number, TC temporal cortex, yr years
aCalculated by Mann-Whitney U-test between AD and CT
bCalculated by Fisher’s exact test for gender distribution
cCalculated by Fisher’s exact test for APOE ε4 allele carrier status (ε4 carrier and ε4 non-carrier)
Data are presented as the mean ± standard deviation