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. 2017 Jan 30;16:13. doi: 10.1186/s12943-016-0571-x

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Leukemia stem cells in AML. Transforming mutations in hematopoietic stem cells (HSC) and/or common myeloid progenitor (CMP) leads to the formation of leukemia stem cells (LSCs), which have mutations in survival signaling pathways and altered self renewal capacity. Chemotherapy can significantly abolish the AML blast cells population while the LSCs survive, and instigate relapse in the future