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. 2017 Jan 31;16:17. doi: 10.1186/s12934-017-0641-9

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic overview of geraniol biosynthesis based on the mevalonate (MVA) pathway in S. cerevisiae. The endogenous genes tHMG1, IDI1 and ERG20 ^WW and heterologous gene tVoGES encoding a truncated version of geraniol synthase from Valeriana officinalis were overexpressed to improve geraniol production in our previous work. The native promoter of ERG20 was replaced with the CTR3 promoter, BTS1 promoter or HXT1 promoter. Other engineered genes in this pathway: OYE2, NADPH oxidoreductase and ATF1, alcohol acetyltransferase. HMG-CoA 3-hydroxy-3-methylglutaryl coenzyme A, IPP isopentenyl pyrophosphate, DMAPP dimethylallyl pyrophosphate, GPP geranyl diphosphate, FPP farnesyl diphosphate