Table 3.
Unadjusted regression models of androgen levels and 12- and 36-month outcomes within each sex
Androgensa | Infant sex | Outcomes | |||||
---|---|---|---|---|---|---|---|
12-month AOSI | 36-month SRS | ||||||
Beta | 95% CI | P | Beta | 95% CI | P | ||
ln(T) | Female (n = 62) | 0.20 | (−0.12,0.51) | 0.22 | −0.06 | (−0.30,0.19) | 0.64 |
Male (n = 75) | 0.20 | (−0.13,0.52) | 0.23 | 0.05 | (−0.25,0.36) | 0.73 | |
ln(A4) | Female (n = 62) | 0.06 | (−0.36,0.48) | 0.78 | −0.18 | (−0.50,0.14) | 0.26 |
Male (n = 75) | 0.06 | (−0.33,0.45) | 0.76 | −0.21 | (−0.57,0.15) | 0.24 | |
ln(DHEA) | Female (n = 62) | 0.09 | (−0.19,0.37) | 0.51 | −0.05 | (−0.25,0.16) | 0.67 |
Male (n = 75) | 0.04 | (−0.28,0.34) | 0.82 | −0.01 | (−0.31,0.29) | 0.94 |
ln natural log transformed
aSeparate robust regression models of loge-transformed testosterone (T), androstenedione (A4), and dehydroepiandrostenedione (DHEA) with total loge (AOSI + 1) and loge (SRS raw) scores. Outcome measures are 12-month Autism Observation Scales for Infants (AOSI) total score and 36-month Social Responsiveness Scale (SRS) total raw score