Fig. 6.

Progressive motor deficits of Line 61 mice measured by four different motor tests. a Time in seconds mice hang on the wire in the wire hanging test. b Latency to fall from the rotating rod in the RotaRod test. c Peaks per gnawing episode in the pasta gnawing test. d Scoring of the nest building test (1 bad nest, 5 perfect nest). a–d n = 10–15 per group; Mean ± SEM. Two-way ANOVA followed by Bonferroni’s posthoc test. b, c 1 outlier excluded. *differences between transgenes. #differences between age groups of one genotype. *p < 0.05; **p < 0.01; ***p < 0.001