Table 1.
Epadel | Vascepa | |
---|---|---|
Year approved | 1988 | 2012 |
Country | Japan | USA |
Generic name | Ethyl icosapentate; icosapent | Icosapent ethyl |
Structure | ||
Molecular formula | C22H34O2 | C22H34O2 |
Molecular weight | 330.50 | 330.51 |
Indications | Hyperlipidemia; improvement of ulcer, pain and cold feeling associated with arteriosclerosis obliterans | Adjunct to diet to reduce TG levels in adults with severe (≥500 mg/dL) hypertriglyceridemia |
Formulation | 300-mg, 600-mg, or 900-mg capsules | 500-mg or 1000-mg capsules |
Dosage and administration | 1.8 g/daya (twice daily after meals) | 4 g/day (twice daily with food) |
aRecommended dosage for treatment of hyperlipidemia; dose may be increased to 1 capsule three times per day if TG levels are abnormal. EPA eicosapentaenoic acid, TG, triglyceride