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. 2017 Jan 31;16:19. doi: 10.1186/s12943-017-0592-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CCR7 activates the Notch signaling pathway in mammary cancer stem-like cells. a-b Hes1 expression was assessed in primary mammary CSCs from PyMT-Ccr7 ^WT and Ccr7 ^−/− tumors. a Hes1 mRNA levels relative to PyMT-Ccr7 ^−/− in the sorted CD24⁺CD29^hi stem cell-enriched population (left) and in secondary mammospheres (right), n = 4–6 mice/genotype/experiment. b Hes1 protein expression in the CD24⁺CD29^hi sorted cell population, n = 4 mice/genotype. c Relative Hes1 mRNA levels in PyMT-Ccr7 ^WT secondary mammospheres cultured with and without CCL19 and CCL21. d Relative Hes1 mRNA levels in PyMT-Ccr7 ^−/− secondary mammospheres cultured with and without CCL19. c–d n = 6 mice/experiment