Fig. 2.

OCA treatment reduces hepatic cholesterol and increases fecal cholesterol contents along with reductions of hepatic TG and fecal BA. Male hamsters fed a HFHCD were orally administered vehicle (n = 8) or OCA at 10 mg/kg (n = 8) for 14 days. Feces were collected on day 0 and day 13 of treatment, dried, and weighed. Hamsters were euthanized and serum and livers were isolated at the termination of the experiment. A, B: Lipids were extracted from individual liver samples and TC and TG were measured. Values are mean ± SEM of eight hamsters per group. **P < 0.01 and ***P < 0.001 as compared with the vehicle control group. C, D: Lipids were also extracted from dried feces and TC and BA were measured. Values are mean ± SEM of four fecal samples per group. *P < 0.05 and **P < 0.01 as compared with the control group.