Fig. 7.

Examination of dose-dependent effects of OCA on the expression of genes involved in BA synthetic pathway and on SR-BI protein abundances in hamsters fed a NCD and treated with OCA for 3 days. A: qRT-PCR analysis of hepatic gene expression in FXR pathway. Values are the mean ± SEM of 5 liver samples per group. *P < 0.05, **P < 0.01. and ***P < 0.001 as compared with the vehicle control group. B: Western blot analysis of hepatic SR-BI protein expression. Values are the mean ± SEM of four randomly chosen liver samples per group.