PTGES1 expression is reduced by HDACi (A, B) or depletion (C). A–C: qRT-PCR of the genes indicated (relative to β-actin) from murine carotid rings (A) and from human VSMCs (B, C). A: Effect of SAHA (2 μmol/l, 14 h). B: Effect of SAHA or apicidin (14 h), both relative to the control DMSO (Ctl). C: Effect of two different control scrambled RNAi (siSCRs) or siRNA against HDAC as indicated. *P < 0.05, n ≥ 3.